Efficacy of Pyrvinium Pamoate against Cryptosporidium parvum Infection In Vitro and in a Neonatal Mouse Model
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چکیده
منابع مشابه
Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.
No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% growth inhibition in human enterocytic HCT-8 cells by a quantitative alkaline phos...
متن کاملEfficacy of pyrvinium pamoate against Cryptosporidium parvum infection in 1 vitro and in a neonatal mouse model 2 3 Running title : Inhibition of
* Corresponding author: David J. Sullivan. Mailing address: Department of Molecular 17 Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 18 615 N. Wolfe St., Baltimore, Maryland 21205, USA. Phone: (410) 502-2522, FAX: (410) 95519 0105. E-mail: [email protected] 20 21 22 23 A CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed A...
متن کاملEfficacy of pyrvinium pamoate against Cryptosporidium parvum infection in 1 vitro and in a neonatal mouse model 2 3 Running title : Inhibition of Cryptosporidium by pyrvinium 4 5 Autumn
* Corresponding author: David J. Sullivan. Mailing address: Department of Molecular 17 Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 18 615 N. Wolfe St., Baltimore, Maryland 21205, USA. Phone: (410) 502-2522, FAX: (410) 95519 0105. E-mail: [email protected] 20 21 22 23 A CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed A...
متن کاملCryptosporidium parvum and Cryptosporidium andersoni infection in naturally infected cattle of northwest Iran
The protozoan intestinal parasite Cryptosporidium commonly infects cattle throughout the world and Iran. The present study was undertaken to determine the abundance and associated risk factors of Cryptosporidium infection in cattle herds of northwestern Iran. A total number of 246 fecal samples from 138 (56.1%) diarrheic (D) and 108 (43.9%) non-diarrheic (ND) cattle were rando...
متن کاملBobel-24 activity against Cryptosporidium parvum in cell culture and in a SCID mouse model.
The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2008
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00207-08